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KMID : 1161420110140010101
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Journal of Medicinal Food
2011 Volume.14 No. 1 p.101 ~ p.107
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Dose?Response Study of Sajabalssuk Ethanol Extract from Artemisia princeps Pampanini on Blood Glucose in Subjects with Impaired Fasting Glucose or Mild Type 2 Diabetes
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Choi Ji-Young
Shin Su-Kyung
Jeon Seon-Min
Baek Nam-In
Chung Hae-Gon
Jeong Tae-Sook
Lee Kyung-Tae
Lee Mi-Kyung
Choi Myung-Sook
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Abstract
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Previously we reported that an ethanol extract from Artemisia princeps Pampanini lowered blood glucose in db/db mice. Here we report a preliminary study in which the blood glucose-lowering effects of two different doses of sajabalssuk ethanol extract (SBE), containing eupatilin and jaseocidin, were examined in hyperglycemic subjects with fasting blood glucose (FBG) levels of 100?150?mg/dL. Subjects were randomized into four groups: negative control (2,000?mg of lactose /day), positive control (1,140?mg of pinitol/day), low-dose SBE (2,000?mg of SBE/day), and high-dose SBE (4,000?mg of SBE/day). After 8 weeks of supplementation, FBG and glycosylated hemoglobin levels were significantly lowered in low-and high-dose SBE groups compared to the baseline values; high-dose SBE also resulted in significantly lower plasma free fatty acid levels and systolic blood pressure. This study demonstrated that supplementation of 2?g or 4?g of SBE daily can significantly reduce blood glucose in hyperglycemic subjects, although high-dose SBE seemed to be more effective than low-dose SBE for lowering plasma free fatty acid level and systolic blood pressure.
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KEYWORD
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Artemisia princeps Pampanini, ethanol extract, fasting blood glucose, free fatty acids, hemoglobin A1c
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